Whenever possible, in close contact with infected persons, especially when they cough or sneeze. A person with a cold is highly contagious, he or she fills the air with fine particles of saliva or mucous membranes that carry the microbe virus. Even if the person takes care of his nose with a tissue or handkerchief, the microbes will be transported to his hands. And studies have shown that these viruses are transmitted by hand contact. So if you're dealing with someone who shook hands with a cold, you'd better wash shortly after!