Systemic Lupus Erythematosus (SLE)

A disease caused by immune complexes. Immune complexes are produced when an antibody response to a soluble antigen. Since the immune response progresses, greater immune complexes formed leading to the activation of complement, activated components that bind to the complexes. These are then efficiently cleared by binding to receptor 1 (CR1) on erythrocytes, the immune complexes across to the liver and spleen form.
 Since the complexes are removed from the red cell surface by Kupffer cells and other phagocytes (fig. a) and taken through a variety of complement and Fc receptors on the cells lining the sinusoids of the liver and spleen circulation. If antigen is repeatedly if released to the formation of small immune complexes to keep these complexes tend to be stuck in the small blood vessels of the kidney glomerulus and synovial tissue of joints. The most common immune-complex diseases are included in Fig. b. In subacute bacterial endocarditis, bacteria reside for a prolonged period on the valves of the heart. The antibody response to the prolonged presence of the bacteria are intense and immune complexes are formed with the bacterial antigens. The immunoglobulin in the immune complexes leads to the formation of anti-IgG antibodies or rheumatoid factor. These complexes are trapped in the glomeruli and cause glomerulonephritis. Similarly, hepatitis virus in the liver is a chronic infection that a strong antibody response and the formation of rheumatoid factor provokes. These immune complexes by the hepatitis virus precipitation in the cold and are therefore called cryoglobulins.

Essential Mixed Cryoglobulinemia). They can also be entrapped in the renal glomeruli and small blood vessels of the skin, nerves and other tissues, where they cause inflammation of blood vessels (vasculitis).

The most common immune complex disease systemic lupus erythematosus (SLE), characterized by the formation of antibodies against DNA.

Every day, millions of nuclei extruded from erythroblasts in the bone marrow as they mature into red blood cells (erythrocytes). This event, among other things, provides a rich source of DNA in those individuals prone to create an immune response to DNA and thus to the development of SLE. So, here are the antigens: DNA, histones, ribosomes, and RNP. All these are in the nuclear compartment.The effects of the deposition of immune complexes: glomerulonephritis, vasculitis and arthritis.

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